Elucidation of the role of intestinal Clabsorption in the fructose-induced hypertention

研究表明，代谢综合征发病率的增加与果糖总摄入量的增加有关。研究还表明，果糖摄入量的增加会刺激NaCl的吸收，从而导致高血压。为了阐明肠道氯离子吸收在果糖诱导的高血压中的作用，我们研究了果糖对大鼠小肠氯离子吸收的影响。然而，高果糖饮食对cl2的吸收没有明显的变化。这表明果糖可能通过未知的机制刺激结肠吸收。因此，我们研究了cl2在小鼠结肠中的吸收机制。我们发现结肠中clt转运机制存在节段性差异。

It has been shown that the increase in the incidence of metabolic syndrome correlates with increase in total fructose intake. It is also shown that increased fructose intake stimulates NaCl absorption and resulted in hypertension. To elucidate the role of intestinal Clabsorption in the fructose-induced hypertension, we examined the effect of fructose on the Clabsorption in the rat small intestine. However, no discernable change was observed in the high-fructose diet on the Clabsorption. This implies that fructose may be stimulate the colonic Clabsorption via unknown mechanism. Therefore, we examined the Clabsorption mechanism in the murine colon. We found that segmental differences in Cltransport mechanism in the colon.