Antibacterial Drug Delivery by Surface Modified Nanoparticle forTreatment of Biofilm Infection Disease

生物膜增加了对洗涤剂和抗生素的抵抗力，因为密集的细胞外基质和细胞外层保护了群落的内部。这些生物膜引起顽固性感染。因此，迫切需要开发用于治疗生物膜感染疾病的抗菌药物递送系统。我们打算设计表面修饰的PLGA纳米颗粒，用于给生物膜中的细菌递送抗菌药物。cs修饰的PLGA NP具有较强的抗菌作用和抑制生物膜的形成。由于cs修饰的NP可以吸附在带负电荷的生物膜上，并将抗菌药物传递到细菌形成的生物膜上，从而形成了CAM的高浓度梯度。因此，cs修饰的PLGA NP在生物膜感染疾病的治疗中具有很大的应用潜力。

Biofilms increased resistance to detergents and antibiotics, as the dense extracellular matrix and the outer layer of cells protect the interior of the community. These biofilms cause the intractable infections. Therefore, the development of antibacterial drug delivery systems for treatment of biofilm infection disease is strongly desired. We intended to design surface modified PLGA nanoparticle for antibacterial drug delivery to the bacteria in the biofilm. CS-modified PLGA NP indicated the strongly antibacterial effect and suppression of biofilm formation. Because CS-modified NP could adsorb on the negatively charged biofilms and deliver antibacterial drug to biofilm formed with bacteria, in which the high concentration gradient of CAM was formed. Therefore, CS-modified PLGA NP has a high potential to be used in biofilm infection disease therapy.