Study for protective and harmful effects of environmental factors on emotional system and its development
Study for protective and harmful effects of environmental factors on emotional system and its development
批准号:
22590118
负责人:
SHIRASAKI Tetsuya
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
运用电生理、神经化学和行为科学等手段,研究了环境因素对早期情感脑功能的影响。心理压力环境会改变受体对单胺和/或氨基酸的功能或对它们的反应。GIRK2和5- ht1受体的表达水平未受影响。短暂但反复的母亲隔离倾向于增加攻击性行为。环境的自然声音,如溪流的声音,不受在单个神经元水平上观察到的短暂但反复的母亲隔离的影响。
英文摘要
We studied how environmental factors in early life stage affectemotional brain functions by using electrophysiological, neurochemical and behavioralscience techniques. Psychologically stressful environments alter receptor functions tomonoamines and/or amino acids or responsiveness to them. Expression levels of GIRK2 and5-HT1Areceptor were not affected. Short but repeated maternal isolation tended to increaseaggressive behavior. Environmental natural sounds such as sounds of a stream protectedfrom the effects observed at single neuron level of short but repeated maternal isolation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Effectsof early life stress on ionic currentsin the CNS neurons and neuro-behaviorsand its attenuation by natural sounds
早期生活压力对中枢神经系统神经元离子电流和神经行为的影响及其对自然声音的衰减
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tetsuya Shirasaki, Ryota Hamasaki,Fumio Soeda, Kazuo Takahama]
通讯作者:
Kazuo Takahama
Maternal isolation affects function of GIRK channels in neurons of the hippocampus but not the raphe nucleus
母体隔离影响海马神经元 GIRK 通道的功能,但不影响中缝核
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tetsuya Shirasaki, Ahmed M. Shehata, Fumio Soeda, Kazuo Takahama]
通讯作者:
Kazuo Takahama
Effects of early life stress on ionic currents in the CNS neurons and behavior and amelioration by exposure to natural sounds.
早期生活压力对中枢神经系统神经元离子电流和行为的影响以及通过接触自然声音得到的改善。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tetsuya Shirasaki, Ryota Hamasaki, Fumio Soeda, Kazuo Takahama.]
通讯作者:
Kazuo Takahama.
Developmental change, effects of stress and GIRK channel inhibitor on GIRK channel function.
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批准号:19590069
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2007
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负责人:SHIRASAKI Tetsuya
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依托单位:
Clarification of the effects of diethylstilbestrol, an endocrine disruptors, on synaptic plasticity and its application as an detailed test
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批准号:15590110
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:SHIRASAKI Tetsuya
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依托单位:
Analysis of nociceptin-induced spontaneous transient outward currents and their physiological function in the CNS
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批准号:11680811
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:SHIRASAKI Tetsuya
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依托单位:
CREATION OF NEW CONCEPT AND ITS MECHANISM IN SYNAPTIC PLASTICITY AT CHOLINERGIC SYNAPSES
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批准号:08680892
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.54万
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财政年份:1996
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负责人:SHIRASAKI Tetsuya
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依托单位:
海外基金