Molecular mechanisms of the physiologically relevant component of the inward rectifier potassium channels that shows low sensitivity to the channel blockers

Kir2内向整流钾通道的外向电流在调节神经细胞和肌肉细胞的功能中起重要作用。我们研究了Kir2电导的分子机制，通过显示对细胞内阳离子阻断剂的低敏感性来携带外向电流。我们的研究表明，低亲和力的电导不能解释由阻断剂诱导的亚电导水平。据证实，动力学的低亲和力堵塞可能是如此之快，单位电导明显整流。

The outward currents of the Kir2 inward rectifier potassium (K) channels play an important role in regulating the functions of neuronal and muscle cells. We studied the molecular mechanisms of the Kir2 conductances that carry the outward currents by showing a low-sensitivity to the intracellular cationic blockers. Our study indicated that the low-affinity conductance cannot be explained by the sub-conductance levels induced by the blockers. It is suggestedthat the kinetics of the low-affinity blockage may be so fast that the unit conductances apparently rectify.