Pathological studies on molecular basis of failure of vascular homeostasis and pathological vascular remodeling.

为了阐明病理性血管重构的分子基础，我们研究了动脉粥样硬化、血管炎和血管生成疾病（肿瘤、糖尿病）。我们发现，血管和淋巴血管生成、炎症、先天免疫等多种因素在遗传和生化水平上控制着血管的完整性。血管稳态的破坏导致血管完整性的丧失和细胞功能的改变，导致病理性血管重构。

To elucidate the molecular basis of pathological vascular remodeling, we investigated on atherosclerosis, vasculitis, and angiogenic diseases (tumor, diabetes mellitus). We found that, various factors, which concerned with angio- and lymph-angiogenesis, inflammation, innate immunity , control the vascular integrity by genetic and biochemical level. The failure of vascular homeostasis lead to loss of vascular integrityand modification of cell function, result in pathological vascular remodeling.