Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer

我们研究了α-DG糖基化在人前列腺癌中的意义。在前列腺癌细胞中，我们发现α-DG糖基化水平的下降比α-DG核心蛋白水平的下降更为明显。这一变化与Gleason分级系统评估的高度浸润性癌组织学类型有关。我们还发现，α-DG上的层粘连蛋白结合多糖表达于基底层细胞的基底侧，在非肿瘤性前列腺组织中，这些多糖与基底膜中的层粘连蛋白共存。这种关联在前列腺癌中是不存在的。

We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.