The population based study of the predictive value of measurement of urinary albumin excretion by the HPLC method on the incidences of cardiovascular diseases and renal diseases.

本研究的目的是：1)检测尿白蛋白排泄量，以预测普通人群中无肾病和心血管疾病的糖尿病患者的糖尿病肾病的未来发展。我们已经建立了大约100名没有肾病的糖尿病门诊患者和大约1300名在基塔秋田市参加年度健康检查的受试者的队列。对基线尿白蛋白排泄量进行了高效液相色谱法和常规法的测定和评价，发现两种方法测定的尿白蛋白有差异。此外，在基塔秋田市的普通人群中，我们发现大约五分之一的人患有慢性肾脏疾病，这是未来发展为肾功能衰竭和心血管疾病的高风险指标。我们将继续对这一队列的心血管疾病的发展进行前瞻性观察。

The objectives of this study are 1) to test the efficacy of measurement of urinary albumin excretion by the novel HPLC method for predicting future development of diabetic nephropathy in diabetic patients without nephropathy and cardiovascular diseases in general population. We have established the cohort of approximately 100 diabetic outpatients without nephropathy and of approximately 1300 subjects who participated in annual health examination at Kita-akita city. Measurement and evaluation of urinary albumin excretions by HPLC and conventional method at the baseline had already done and we have found that the discrepancy of the urinary albumin values between HPLC method and conventional one. Also, in the general population of Kita-akita city, we found that approximately one fifth of people have chronic kidney disease, that is the indicator of high risk of future development of renal failure and cardiovascular diseases. We will continue prospective observation of this cohort regarding the development of cardiovascular diseases.