Serum miRNA Levels in Patients with Inflammatory Bowel Disease

我们检测了应用抗肿瘤坏死因子α抗体治疗克罗恩病的标准分子靶向治疗前后的血清miRNA。结果显示，12个miRNAs发生了变化。缓解组与未缓解组比较，缓解组let-7d和let-7e均升高。检测血清LET-7的分子生物学意义。它可能参与引起炎症的T淋巴细胞的凋亡。因此，let-7可能成为难治性克罗恩病的治疗标志物。

We measured serum miRNA before and after the antiTNF alpha antibody administration that was standard molecular target therapy of the Crohn's disease. As a result, showed a change in 12 miRNAs. Also, in the comparison between remission group and non-remission group, we confirmed that let-7d and let-7e were increased in a remission group. The molecular biologic significance of serum let-7 should be examined. It may be involved in apoptosis of T lymphocytes causing inflammation. As a result, let-7 may become a therapeutic marker of the refractory Crohn's disease.