Establishing the biomarker of multiple system atrophy

为了评估多系统萎缩（MSA）患者脑退化的进展，我们使用基于体素的形态学（VBM）、磁共振成像的平均扩散率（MD）和分数各向异性（FA）进行了前瞻性分析。我们从登记开始每6个月评估17例可能的MSA患者的VBM、MD和FA，为期2年，并使用基于体素的分析技术将他们的发现与17名健康对照进行比较。VBM、MD和FA表现为大脑退行性病变主要在额叶，尤其是前额叶皮层进行性扩散，随后扩散到颞叶和顶叶，2年后最终扩散到枕叶。VBM、FA和MD在MSA中表现出明显的脑受累进展模式。同时评估VBM、FA和md可以深入了解MSA中大脑异常的特征和疾病进展的潜在定量生物标志物。

To assess the progression of brain degeneration in patients with multiple system atrophy (MSA), we conducted prospective analyses using voxel-based morphometry (VBM), mean diffusivity (MD), and fractional anisotropy (FA) of magnetic resonance imaging. We evaluated VBM, MD and FA in 17 probable MSA patients every 6 months from registration for 2 years, and compared their findings to those of 17 healthy controls using a voxel-based analysis technique. VBM, MD and FA showed the progressive spread of cerebral degeneration mainly in the frontal lobe, especially the prefrontal cortex, subsequently spreading to the temporal and parietal lobes, and finally to the occipital lobe after 2 years. VBM, FA, and MD showed the distinct progression pattern of cerebral involvement in MSA. The simultaneous evaluation of VBM, FA, andMD can provide an insight into the features of cerebral abnormalities in MSA and potential quantitative biomarkers of disease progression.