Study of Insulin resistance involving impaired GLUT4 translocation

有缺陷的胰岛素反应性GLUT4易位是胰岛素抵抗最早可检测到的特征。生化和纳米计量学分析表明，sortilin是vps10p家族分选受体的一员，在建立反式高尔基网络系统中起关键作用，该网络专门用于产生胰岛素反应的glut4 -奇异囊泡，在某些胰岛素抵抗条件下出现严重紊乱。因此，这项研究揭示了胰岛素抵抗不仅是由胰岛素信号缺陷引起的，也是由GLUT4运输本身的损伤引起的（“分类障碍”）。

Defective insulin-responsive GLUT4 translocation is the earliest detectable feature of insulin resistance. Biochemical and nanometrological analyses herein revealed that sortilin, a member of the Vps10p-family sorting receptor, plays a critical role in establishing trans-Golgi network system specialized for generating the insulin-responsive GLUT4-strage vesicles that emerged to be severely deranged under certain insulin resistant conditions. This study thereby unmasks that insulin resistance is caused by not only defects in insulin signaling but also impairment of GLUT4 trafficking itself (“sorting disorder").