The elucidation of antihyperglycemic action mechanism in the liver and pancreatic beta cells of bile acid resin

本研究的目的是评价胆汁酸隔离剂Colstiide对2型糖尿病患者糖代谢的慢性影响。Colstiide可显著降低升高的空腹血糖水平，而CA更显著地降低空腹血糖。一项高胰岛素-正常血糖钳夹研究显示，考斯替胺通过抑制肝脏葡萄糖生成和增加外周葡萄糖使用量来缓解胰岛素抵抗。Colstiide抑制SHP的表达，但增强SREBP2的表达。CA可促进SHP和ACC、SCD-1等造脂酶的表达，但对SREBP2无影响。

The objective of this study was to assess the chronic effects of a bile acid sequestrant, colestimide, on glucose metabolism in type 2 diabetes..Colestimide significantly reduced the elevated fasting blood glucose level, and CA even more markedly reduced fasting blood glucose. A hyperinsulinemic-euglycemic clamp study revealed that colestimide alleviated insulin resistance by suppressing hepatic glucose production and increasing peripheral glucose usage. Colestimide suppressed SHP expression, but enhanced SREBP2 expression. On the other hand, CA increased the expression of SHP and lipogenic enzymes such as ACC and SCD-1, but had no effect on SREBP2.