Effect of histamine H4 and H1 receptor on allergic diseases

组胺促进慢性变应性接触性皮炎湿疹性病变的发展。除了众所周知的皮质类固醇治疗外，还使用了组胺H1受体（H1 R）拮抗剂。本研究观察了组胺H4受体（H4 R）拮抗剂与H1 R拮抗剂联合使用对小鼠慢性变应性接触性皮炎模型的影响，该模型通过反复经皮激发背部皮肤2，4，6-三硝基-1-氯苯（TNCB）而建立。然后给予H1 R拮抗剂盐酸奥洛他定和/或H4 R拮抗剂JNJ 7777120。联合治疗比H1 R拮抗剂单药治疗更有效。湿疹皮损中IL-4、IL-5和IL-6（Th 2细胞因子）水平和血清IgE水平在联合治疗后均下降。H1 R和H4 R拮抗剂的联合治疗抵消了各自作为单药的缺点，并可能代表治疗慢性变应性接触性皮炎的新策略。

Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatment, histamine H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 were then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.