Approaches for the development of therapeutic tools of chronic pruritic and allergic diseases via targeting against eosinophils and basophils

瘙痒伴随着各种过敏性皮肤病。瘙痒症极大地损害了日常生活的质量。在本项目中，通过各种嗜酸性粒细胞和/或嗜碱性粒细胞浸润的小鼠过敏模型，分析了慢性变态反应性炎症和瘙痒的机制。嗜酸性粒细胞和嗜碱性粒细胞上表达的PGD2受体被认为是治疗慢性过敏性皮炎的良好靶点。嗜碱性粒细胞中选择素配体的产生似乎是嗜碱性粒细胞向皮肤募集的关键步骤，因此，选择素也可能成为治疗嗜碱性粒细胞依赖型皮肤病的潜在靶点。

Itch accompanies various allergic skin diseases. Pruritus greatly impairs the quality of daily life. In this project, mechanisms of chronic allergic inflammations and itch were analyzed with various mouse allergic models where eosinophil and/or basophil infiltration is prominent. Receptors for PGD2 expressed on eosinophils and basophils were found to be promising therapeutic target for chronic allergic skin inflammations. Selectin-ligand generation in basophils appeared to be a key step for basophil recruitment to the skin, and thus, selectins also could be a potential therapeutic target for basophil-dependent skin diseases.