Simultaneous fMRI-EEG Recording of MMN in Schizophrenia

各记录方式的数据与临床表现（EEG、fMRI、PANSS）均有显著相关性。这些相关性支持本fMRI实验中获得的BOLD激活反映了通过ERP方法记录的MMN生成的等效生理机制。SPM相关分析显示右侧前扣带、右侧胼胝体和右侧脑岛的BOLD活动与一般症状、阴性症状和阳性症状的PANSS评分有显著相关。脑岛、钩状束和胼胝体以及颞叶和前扣带回的功能障碍可能是精神分裂症患者MMN畸变的特异性原因，其临床表现反映了其MMN生成受损。观察到BOLD活动与PANSS评分呈正相关，可能反映了精神分裂症患者的超敏或注意力不集中。

Significant correlations were obtained among data of each recording modality and clinical manifestations, i.e. EEG, fMRI, and PANSS. These correlations support that the BOLD activation obtained in the present fMRI experiment reflects equivalent physiological mechanism of MMN generation recorded via ERP methods.The correlation analysis on SPM revealed significant correlation between BOLD activity of the right anterior cingulate, the right corpus callosum and right insula and PANSS scores of general, negative, and positive symptoms respectively.The dysfunction of Insula, the uncinate fasciculus and the corpus callosum, as well as the temporal lobe and the anterior cingulate gyrus, may specifically contribute to MMN aberration of schizophrenic patients and clinical manifestations reflecting their impaired MMN generation.Observed positive correlation between BOLD activities and PANSS scores may reflect hypersensitivity or distractibility of schizophrenic patients.