Molecular biologic effect of neoadjuvant chemoradiotherapy followed by surgery for non-small cell lung cancer

通过分析局部晚期非小细胞肺癌新辅助放化疗(NACRT)前后的影像诊断和手术标本的病理诊断，揭示NACRT的治疗效果和影像诊断能力。11例中6例完全缓解(CR)。在非CR病例中，50%~80%的细胞形态有活力，DNA双链断裂，增殖指数降低。影像诊断分析结果显示，18F-脱氧葡萄糖摄取减少率和弥散加权像高信号消失反映了良好的治疗效果。目前的研究显示了NACRT的有效性和功能成像导致量身定制治疗的可能性。

Treatment effect of neoadjuvant chemoradiotherapy (NACRT) and diagnosis ability of imaging was revealed by analyzing the diagnostic imaging before and after NACRT and pathological diagnosis of surgical specimens of locally advanced non-small cell lung cancer. Complete remission (CR) was observed in 6 among 11 cases. Fifty to 80% of morphologically viable cells of the non-CR cases showed double strand breaks of DNA and decreased the proliferating index. Results of analyses of imaging diagnosis showed that reduction rate of 18F-fluorodeoxy glucose uptake and disappearance of high signal intensity on diffusion weighted image reflected the good treatment effect. The present study showed efficacy of NACRT and the potential that a functioning image leads to the tailor-made treatment.