The clarify of the mechanism of induction of immunological tolerance using mouse liver transplantation model and development of novel immunosuppression.

为了在器官移植中发展新的免疫抑制，我们分析了原位小鼠肝移植的移植接受机制，该移植可以在不使用免疫抑制药物的情况下诱导免疫耐受。这表明共刺激分子之一的PD-1/PD-L1通路对移植物接受至关重要。并分析了与异体移植排斥或接受相关的microRNA。提示骨髓源性抑制细胞在抑制移植排斥反应中具有重要作用。

For the development of novel imunosuppression in organ transplantation, we have analyzed the mechanism of graft acceptance using orthotopic mouse liver transplantation, which can induce immunological tolerance without immunosuppressive drugs. It shows that one of the co-stimulatory molecule, PD-1/PD-L1 pathway is essential for graft acceptance. And it has analyzed that microRNA which associated with rejection or acceptance of allografts. And it suggested that myeloid-derived suppressor cells has an important role for inhibition for graft rejection.