Analysis of immunity induction in rectal cancer in association with microscopic abscess formation

我们研究了MAF阳性和阴性肿瘤之间的基因谱。包括toll样受体7 （TLR7）在内的11个基因在MAF阳性肿瘤中过表达。我们重点研究了TLR7的下游成分髓样分化因子88 （MyD88）。RT-PCR结果显示，与MAF阴性肿瘤相比，MyD88在MAF阳性肿瘤中表达下调。我们的数据表明，在MAF阳性肿瘤中，MyD88的低表达与预后较好有关。有趣的是，尽管MyD88的表达是由TLR7介导的，但在MAF阳性肿瘤中，TLR7和MyD88的表达存在差异。我们估计除TLR7外，其他基因在MAF阳性肿瘤中调节MyD88的表达。

We investigated gene profile between MAF positive and negative cancer. Eleven genes including Toll-like receptor 7 (TLR7) were overexpressed in MAF positive cancer. We focused on myeloid differentiation factor 88 (MyD88), the downstream component of TLR7. RT-PCR demonstrated that MyD88 was downregulated in MAF positive cancer, compared with MAF negative cancer. Our data indicated that lower expression of MyD88 is related with their better prognosis in MAF positive cancer. Interestingly, nevertheless MyD88 expression is mediated by TLR7, the discrepancy exists between expression of TLR7 and MyD88 in MAF positive cancer. We estimate that other genes except TLR7 regulate MyD88 expression in MAF positive cancer.