Influence of mesenchymal stem cells on intestinal tissue engineering combined with Bianchi's procedure using small intestinal submucosa

小肠粘膜下层（SIS）是一种富含胶原的生物可降解基质，含有功能性生长因子。在这项研究中，我们研究了SIS与间充质干细胞（MSC）联合用于胃肠道再生的可行性。此外，我们还研究了SIS作为生物支架与小肠组织工程和比安奇手术相结合的可移植性。接种的MSC提供了一个丰富的环境，支持SIS移植物在工程胃中的组织再生。SIS具有用作促进物理和生理性新肠形成的支架的潜力，这意味着我们的建议接近一种新的手术治疗，即使是在短肠综合征患者中。

Small intestinal submucosa (SIS) is a biodegradable collagen-rich matrix containing functional growth factors. In this study, we investigated the feasibility of SIS in conjunction with mesenchymal stem cells (MSCs) for regeneration of the gastrointestinal tract. Also, we examined the achievability of SIS as a bioscaffold when combined with small intestinal tissue engineering and Bianchi’s procedure. Seeded MSCs provided an enriched environment that supported tissue regeneration by the SIS graft in the engineered stomach. SIS has the potential for use as a scaffold that promotes the formation of a physical and physiological neointestine, which means that our proposal approaches a novel surgical treatment even in patients with short bowel syndrome.