Antitumor effect of Chelated Endostatin

我们评价了分泌螯合内皮抑素的螯合内皮抑素生成载体的抗肿瘤作用。我们在BALBC小鼠的侧腹壁注射Lewis肺癌细胞（1×10^6）。当产生的癌结节体积达到100mm^3in时，我们开始使用内皮抑素转染和/或抗癌药物（DTX, 5-FU）进行化疗。然后评价其抗肿瘤作用。内皮抑素转染是通过在癌结节周围直接注射质粒进行的。不幸的是，我们没有发现内皮抑素转染积累抗癌药物的任何优势。

We have assessed antitumor effect of chelated endostatin generating vector which secret chelated endostatin. We injected Lewis lung cancer cells (1×10^6) at the lateral abdominal wall of the BALBC mice. When the produced cancer nodule became 100mm^3in a volume, we started chemotherapy using endostatin transfection and/or anticancer agents (DTX, 5-FU). Then antitumor effect was assessed. Endostatin tranfection was performed by direct injection with plasmids surrounding the cancer nodule. Unfortunately we could not find any advantages of endostatin transfection accumulating anticancer agents.