The role of MMP and PAR in the pain of the work-related upper limb musculoskeletal disorders

在与工作相关的上肢肌肉骨骼疾病中，如腕管综合征和狭窄性腱鞘炎，症状持续时间与疼痛严重程度呈负相关，与残疾呈正相关。病理结果显示，肥大细胞胰蛋白酶（Mtriptase）是PAR 2的激动剂，主要表达于血管周围。肥大细胞胰蛋白酶与TNF-α、IL-6等细胞因子呈正相关。我们认为这些因素与疼痛的严重程度有关。随着病程的进展，雷公藤多甙酶的表达逐渐减少，VEGF的表达逐渐增加。我们认为肥大细胞胰蛋白酶在肌腱滑膜炎症和疼痛的严重程度中起重要作用。

In work-related upper limb musculoskeletal disorders such as carpal tunnel syndrome and stenosing tenosynovitis, symptom duration correlated negativelywith pain severity and positively with disability. In pathological finding of tenosinovium, mast cell triptase which is an agonist of PAR2 was mainly express around vessels. Mast cell triptase correlated positively with cytokines such as TNF-α and IL-6. Weconsider that these factors were involved in pain severity. The expression of triptase decreased and the expression of VEGF increased over the course of the disease. Wethink that mast cell triptase plays an important role in the inflammation of the tenosynovium and pain severity.