Roles of hypothalamic S6 kinase on diabetes

(1)与对照组相比，db/db小鼠肝脏中LKB1的表达降低。LKB1表达载体对db/db小鼠肝脏的修复改善了血糖控制。(2)表达载体抑制下丘脑弓形核中S6激酶上游调控因子PTEN，可抑制食物摄入和体重增加，但这种作用因过度喂养而减弱。弓形核中PTEN的抑制改善了与体重无关的胰岛素敏感性。

(1) The expression of LKB1 in the liver of db/db mouse was decreased compared to the control mouse. LKB1 rescue in db/db mouse liver by expression vector improved glycemic control.(2) Inhibition of PTEN, the upstream regulator of S6 kinase, in the hypothalamic arcuate nucleus by an expression vector suppressed food intake and body weight gain, but this effect was blunted by overfeeding. PTEN inhibition in the arcuate nucleus improved insulin sensitivity independent to body weight.