Role for Gab family in regulation of pancreatic beta cell mass

在胰腺β细胞中表达的Gab 1和Gab 2在EGF刺激下迅速酪氨酸磷酸化。结果表明Gab家族衔接蛋白参与EGF驱动的β细胞增殖。我们通过检测Gab 1和Gab 2双基因敲除小鼠的表型，探讨了Gab家族在β细胞功能及其增殖中的可能意义。虽然成功产生了β细胞特异性Gab 1/Gab 2双KO小鼠，但其葡萄糖耐量和β细胞质量与对照小鼠相当。这些结果表明Gab家族不参与β细胞群的调节。其他可能性可能涉及其他Gab家族成员（如Gab 3）在β细胞群调节中的补偿作用。

Gab1 and Gab2 expressed in pancreatic beta cells were rapidly tyrosine phosphorylated in response to EGF stimulation. The result suggested involvement of Gab family adaptor proteins in EGF-driven beta cell proliferation. We explored a possible implication of Gab family in beta cell function and its proliferation by examining phenotype of double KO mice for Gab1 and Gab2. While beta-cell specific-Gab1/Gab2 double KO mice were successfully generated, their glucose tolerance and beta cell mass was comparable to those of control mice. These results suggested that no involvement of Gab family in regulation of beta cell mass. Other possibility may involve compensatory roles for other Gab family member, such as Gab3, in the regulation of beta cell mass.