The examination of oxidative stress and endoplasmic reticulum stress in diabetes mellitus.
The examination of oxidative stress and endoplasmic reticulum stress in diabetes mellitus.
糖尿病氧化应激和内质网应激的检查。
批准号：
22790873
负责人：
NAKATANI Yoshihisa
金额：
$2.25万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
中文摘要
翻译
在糖尿病中，ASK-JNK通路与氧化应激和内质网应激密切相关。因此，我们可以认为该途径是改善胰岛素抵抗的关键途径。此外，调整这种ASK-JNK通路可以成为2型糖尿病患者的治疗靶点，并有望在未来这种干预措施导致糖尿病并发症的预防和缓慢进展。
英文摘要
In diabetes, ASK-JNK pathway is considerably involved to oxidative stress and endoplasmic reticulum stress. So, we could think that this pathway was key pathway to improve insulin resistance. Moreover, to adjust this ASK-JNK pathway it can become a therapeutic target to type 2 diabetic patients, and it expects a possibility that this intervention will lead to prevention and slowly progression of diabetic complication in the future.
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