Analysis of the effects of TIM-1 on respiratory epithelial cells on bronchial asthma
Analysis of the effects of TIM-1 on respiratory epithelial cells on bronchial asthma
批准号:
22790973
负责人:
KOBAYASHI Norimoto
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
为了评估TIM-1对呼吸道上皮细胞的功能,使用人II型肺泡上皮细胞系A549。A549细胞表面高表达TIM-1,但不能吞噬凋亡细胞。此外,A549在每个细胞克隆中具有不同的TIM-1突变。这些突变可能影响TIM-1和凋亡细胞之间的结合。
英文摘要
To access the function of TIM-1 on respiratory epithelial cells, the human type II alveolar epithelium cell line A549 was used. Although A549 expressed high level of TIM-1 on the cell surface, it was not able to phagocyte apoptotic cells. Moreover, A549 has different TIM-1 mutations among each cell clone. These mutations probably affect the binding between TIM-1 and apoptotic cells.
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