Influence of fetal growth restriction on gastrointestinal function in preterm infants

为了确定胎儿生长受限对代谢综合征(MS)标志物的影响，我们评估了早产儿出院时的血脂和载脂蛋白代谢。早产儿出院时采血，分为出生体重与胎龄相适应的早产儿组(SGA组)和出生体重与其胎龄相适应的早产儿组(AGA组)。测定血清总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白AI、载脂蛋白B水平，计算总胆固醇/高密度脂蛋白、低密度脂蛋白/高密度脂蛋白、载脂蛋白B/载脂蛋白AI的比值。SGA组总胆固醇/高密度脂蛋白、低密度脂蛋白/高密度脂蛋白和载脂蛋白B/载脂蛋白AI比值明显高于AGA组。我们的数据表明，胎儿发育不良可能会影响早产儿的脂代谢(MS的标志物)。

To determine the influence of fetal growth restriction on markers of metabolic syndrome(MS), we assessed lipid and apolipoprotein metabolism at discharge in preterm infants. Blood samples were collected at discharge from preterm infants divided into a group whose birth weight was small for their gestational age(SGA group) and a group whose birth weight was appropriate for their gestational age(AGA group). Serum T-cho, HDL, LDL, apo AI and apo B levels were measured, and the ratios of T-cho/HDL, LDL/HDL and apo B/apo AI were calculated. T-cho/HDL, LDL/HDL and apo B/apo AI ratios were significantly higher in the SGA group than in the AGA group. Our data suggest that poor fetal growth may affects lipid metabolism(the markers of MS) in preterm infants.