Study on disability of the acoustic sense memory in adult with slightly developmental disorder

比较了54例成人AD/HD患者、43例精神分裂症患者和40例年龄匹配的健康志愿者的事件相关电位（ERP），如Nd、N2 b和P300。N2 b和P300分别反映选择性注意、自主性注意和认知语境更新。成人AD/HD组和SZ组P300的峰值幅度显著低于HC组。SZ组的晚期Nd、N2 b和P300的峰值潜伏期显著长于HC和成人AD/HD组。因此，SZ组中各种ERP成分的振幅衰减和潜伏期延长表明认知加工基础机制受损的可能性。与SZ组不同，成人AD/HD组表现出P300振幅降低，但潜伏期不延长。这些发现表明，在成人AD/HD组中存在不同类型的认知功能障碍，这可能与注意功能密切相关。

Event-related potentials (ERPs) such as Nd, N2b, and P300 were compared among 54 adult AD/HD patients, 43 schizophrenic patients (SZ), and 40 healthy age-matched volunteers (HC). It is known that Nd, N2b, and P300 reflect selective attention, voluntary attention, and cognitive context updating respectively. The peak amplitude of P300 was significantly lower in the adult AD/HD and SZ groups than in the HC group. The peak latencies of late Nd, N2b, and P300 were significantly longer in the SZ group than in the HC and adult AD/HD groups. Thus, attenuated amplitude and prolonged latency of various ERP components in the SZ group suggest the possibility of impairment of basic mechanisms underlying cognitive processing. Unlike the SZ group, the adult AD/HD group exhibited reduced amplitude of P300 but not prolonged latency. These findings suggest the existence of a different type of cognitive dysfunction in the adult AD/HD group, which might be closely related to attentional function.