Radiation therapy for thrombocytopenia due to splenomegaly of liver cirrhosis

肝细胞癌（HCC）对放射治疗和细胞毒化疗具有天然耐药性，使手术成为主流治疗方法。另一方面，众所周知，血小板具有血栓形成作用。然而，血小板不仅在止血方面，而且在伤口愈合和组织再生中发挥重要作用。有报道称，扩大肝切除术后，血小板在肝内积聚并促进肝再生，但其机制尚不清楚。脾肿大伴肝硬化患者血小板减少，阻碍了药物治疗，许多患者放弃了药物治疗。放射线照射被认为是良好的适应，脾肿大的恶性肿瘤，如淋巴瘤，如果减少血小板改善放射线照射的一个例子与不良反应，化疗等也增加了良性疾病。脾功能亢进伴肝硬化血小板减少是一种顽固性疾病，可作为有效的放射治疗手段。本研究的目的是探讨目前尚不保险的放射治疗在治疗肝硬化脾肿大引起的血小板减少症中的临床应用。

Hepatocellular carcinoma(HCC) is naturally resistant toradiotherapy and cytotoxic chemotherapy, leaving surgery as the mainstream therapeuticapproach. On the other hand, it is well known that platelets have a thrombotic effect. However, platelets play an important role not only in hemostasis but also in wound healingand tissue regeneration. Platelets have been reported to accumulate in the liver andpromote liver regeneration after an extended hepatectomy, but the mechanism is unclear. The decrease of platelets of splenomegaly accompanying liver cirrhosis obstructs medicaltreatment, and gives up medical treatment in many cases. Radiation irradiation isconsidered as good adaptation, to splenomegaly by malignant tumors, such as a lymphoma, if the decrease of platelets improves by radiation irradiation in an example with a badreaction, etc. to chemotherapy is increasing also with the benign disease. The decreaseof platelets by hypersplenism accompanying liver cirrhosis is intractable, and can serveas the medical treatment method with effective radiotherapy. Here, the aims of this studyat exploring clinical application of the radiotherapy which is not the present insuranceadaptation as a cure for the plastocytopenia by the splenomegaly accompanying livercirrhosis in this research.