Development of novel molecular target therapy using high expression protein in prostate cancer

为了开发新型前列腺癌分子靶向治疗药物，我们对3种在前列腺癌组织中表达高于癌旁组织的候选蛋白进行了肿瘤特异性和肿瘤生长抑制作用的评价。提示微染色体维持复合物组分5是最有希望的靶点。此外，另一个新的候选肽疫苗鉴定与质谱分析的前列腺癌细胞系。它们可能成为前列腺癌治疗的一个新的分子靶点。

To development novel molecular target therapy for prostate cancer, we evaluated prostate cancer specificity and tumor growth suppression effect of three candidate protein, which expressed higher in prostate cancer compared with adjacent non-cancerous area. It was suggest that Minichromosome maintenance complex component 5 was the most promising target. Moreover, another novel candidate of peptide vaccine was identified with analysis of mass spectrometry in prostate cancer cell lines. They might be a novel molecular target of prostate cancer.