The Anti-inflammatory Effect of Resveratrol in Diabetic Retina

白藜芦醇是已知的抗氧化剂多酚之一。本研究旨在探讨白藜芦醇对糖尿病视网膜的影响。糖尿病模型小鼠口服白藜芦醇治疗7天。白藜芦醇的应用显著减少了白细胞与糖尿病小鼠视网膜血管的黏附。此外，白藜芦醇治疗的糖尿病动物显示视网膜炎症分子显著减少，这些分子在糖尿病诱导后上调。目前的数据表明，白藜芦醇可能被用作糖尿病视网膜病变的治疗剂。

Resveratrol is known as one of antioxidant polyphenols. The purpose of the present study was to investigate the effect of resveratrol on the diabetic retina. The diabetic model mice were orally treated with resveratrol for seven days. Administration of resveratrol significantly reduced leukocyte adhesion to the retinal vessels of diabetic mice. In addition, the diabetic animals treated with resveratrol showed a significant decrease in retinal inflammatory molecules, which were upregulated following the induction of diabetes. The current data suggest the potential use of resveratrol as a therapeutic agent for diabetic retinopathy.