Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feeding

迷走神经传入神经感知周围因素并将这些信号传递给大脑以调节食物摄入。本研究通过测定原代培养的迷走神经传入神经细胞内Ca^<2+>浓度，探讨外周因子是否直接作用于迷走神经传入神经。我们发现一些胰腺和胃肠激素直接激活迷走神经传入神经元。此外，胰岛素对迷走神经传入神经元的作用被胃饥饿素抑制，并被GLP-1增强。

Vagal afferents sense the peripheral factors and convey these signals to the brain to regulate food intake. In present study, I measured cytosolic Ca^<2+> concentration in the primary cultured neurons of vagal afferents to investigate whether peripheral factor directly act on the vagal afferents. We have found that some of pancreatic and gastrointestinal hormones activate vagal afferents neurons directly. Moreover, the insulin action to vagal afferent neurons was suppressed by ghrelin and potentiated by GLP-1.