Analysis of the X chromosome inactivation-reactivation cycle throughout the mouse life cycle

已知雌性哺乳动物的X染色体在整个生命周期中呈现失活-再活化的循环，尤其是在围着床期，X染色体活性的变化发生在较短的时间内。在这项研究中，它表明，重新失活的X染色体在外胚层，未来的胚胎适当的，发生后不久植入。进一步阐明了原始生殖细胞中X染色体再激活过程中失活X连锁基因的DNA甲基化动态。

It is known that the X chromosome of female mammals shows inactivation-reactivation cycles throughout the life cycle, especially at the peri-implantation stage, the changes of the X chromosome activity occur during short period. In this study, it was indicated that the re-inactivation of the X chromosome in the epiblast, the future embryo proper, occurs just after implantation. Furthermore, the dynamics of the DNA methylation of the inactive X linked genes during the X reactivation in primordial germ cells was elucidated.