Development of design of antiviral drug by substitution of carbohydrate ligand for peptide

在感染过程的初始阶段，流感病毒与宿主细胞表面的碳水化合物受体结合。基于碳水化合物配体取代多肽的概念，提出了多肽药物的设计方法。模拟糖肽对多种菌株的病毒感染表现出抑制活性。此外，用单糖对多肽进行化学修饰，表明该多肽具有最高的抑制活性。这导致了设计新型抗病毒药物的有前途的方法。

Influenza virus binds to carbohydrate receptors on the host cell surface at an initial step in the infection process. The method to design of peptide drug was developed based on the concept of substitution of carbohydrate ligand for peptide. The carbohydrate-mimetic peptides showed inhibitory activity for virus infection among multiple types of strain. Furthermore chemical modification of peptide with monosaccharide indicated that the peptides have the highest inhibitory activity. This resulted in the promising methodology for design of novel antiviral drugs.