Molecular and functional analysis of bioactive factor AGF in biological control system

我们使用血管生成素相关生长因子（AGF）转基因小鼠研究AGF的功能。AGF在棕色脂肪组织和骨骼肌中以独立于其促血管生成功能的方式调节能量代谢的增强。此外，为了检查短的冷诱导产热和跑步机运动，我们发现AGF转基因小鼠在跑步机运动中进行了更多的工作，并且在冷诱导产热时体温的下降明显低于野生型对照小鼠。综上所述，我们认为AGF不仅能上调能量代谢，还能上调运动能力和预防体温过低。

We investigated the function of angiopoietin-related growth factor(AGF) using AGF transgenic mice. AGF regulates enhancing of energy metabolism in a manner independent of its proangiogenic function in brown adipose tissue and skeletal muscle. Furthermore, to examine short cold-induced thermogenesis and treadmill exercise, we found that AGF transgenic mice performed significantly more work in treadmill exercise and a significantly less decline in body temperature at cold-induced thermogenesis than the wild-type control mice. Taken together, we suggested that AGF upregulates not only energy metabolism but also exercise capacity and the prevention of hypothermia.