Development of measurement system of drug efflux transporter activity

在本研究中，开发了一种用于测量抗癌药物通过ATP结合盒（ABC）转运体的转运效率的系统，该转运体与耐药性有关。该系统利用荧光成像从微室阵列制造使用半导体微加工技术。虽然使用培养的细胞进行了系统条件的初步研究，但该系统可能成为用于确定从患者收集的癌细胞中的药物转运效率的基本测定系统。

In this research, a system to measure the transportation efficiency of anti-cancer agents via ATP-binding cassette(ABC) transporter, which is involved in drug resistance, was developed. This system utilizes fluorescent imaging from a microchamber array fabricated using semiconductor microfabrication technology. Although a preliminary study of the system conditions was conducted using cultured cells, this system may possibly become the basic assay system for determining the drug transportation efficiency in cancer cells harvested from patients.