Functional analysis of NLRR-4 gene in the mouse olfactory system during development.

在本研究中，我研究了NLRR-4在嗅觉系统发育过程中的表达。我发现NLRR-4在嗅上皮、嗅球和梨状皮质中表达。在犁鼻器官中，在信息素受体v2r阳性的上皮细胞中检测到NLRR-4，而在v1r阳性的上皮细胞中检测不到。在行为分析中，nlrr -4基因敲除的雄性小鼠对其他小鼠的攻击反应减少，对雄性尿液的回避行为减少。这些结果表明NLRR-4参与了嗅觉系统的发育和犁鼻系统的功能。

In this study, I investigated the expression of NLRR-4 in the olfactory system during development. I found that NLRR-4 was expressed in the olfactory epithelium, olfactory bulb, and piriform cortex. In the vomeronasal organ, NLRR-4 was detected in pheromone receptor V2R-positive-epiterial cells but not in V1R-pisitive cells. In the behavioral analysis, NLRR-4-gene knockout male mice showed reduction of the aggressive responses for the other mile mice and the avoidance behavior for male urine. These results suggested that NLRR-4 was involved in the development of the olfactory system and the function of vomeronasal system.