Analysis of Dickkopf molecule in Ewing's sarcoma

DKK1抑制Wnt3a诱导的Ewing肉瘤细胞中β-catenin的核积累，提示DKK1抑制这些细胞中的经典WNT信号。虽然DKK1在Ewing肉瘤异种移植模型中抑制肿瘤的形成，但在标准细胞培养环境中添加DKK1似乎不影响肿瘤的形成和增殖。肿瘤的形成可能通过抑制血管生成等机制在体内受到抑制。

DKK1 suppress nuclear accumulation ofβ-catenin induced by Wnt3a in serum starved Ewing's sarcoma cells and it is suggested that the DKK1 inhibit classical WNT signal in these cells. Although DKK1 suppress tumor formation in xenotranplatation model of Ewing's sarcoma, DKK1 added in the standard cell culture environment seems not to affect tumor formation nor proliferation. Tumor formation might be suppressed in vivo via mechanisms, like suppression of angiogenesis.