X-ray crystallographic analysis of an ABC transporter

了解ABC蛋白的作用机制，并开发针对ABC蛋白的新治疗策略，将大大加快三维结构的形成。用多波长反常色散(MAD)方法测定了单细胞真核生物的ABC转运蛋白的晶体结构。这项研究获得的分辨率是迄今为止报道的真核ABC蛋白中最好的。

Understanding the mechanism of action of ABC proteins and developing new therapeutic strategies that target ABC proteins would be considerably accelerated with the three-dimensional structures. Crystal structure of an exporter-type ABC transporter from a unicellular eukaryote was determined by the multiwavelength anomalous dispersion(MAD) method using the X-ray diffraction data measured at SPring-8. The resolution obtained in this study is best among those of eukaryotic ABC proteins ever reported to date.