Analysis of intestinal NK cells in pathology of inflammatory bowel diseases and examination about translatability of NK cells

我们发现NKp44+/NKp46+NK细胞在人正常肠黏膜中是平衡的，而在克罗恩病肠黏膜中这种平衡被扰乱。此外，肠道NKp46+NK细胞与CD14+LPMφs的相互作用是克罗恩病发病的重要参与者。IL-23和TL1A是它们相互作用的关键因素。这些发现提示IFN-γ产生NKp46+粘膜NK细胞亚群参与了克罗恩病的发病机制。

We showed that the NKp44+/NKp46+NK cell is balanced in human normal intestinal mucosa, and the balance is disturbed in the intestinal mucosa in Crohn's disease. Moreover, the interaction between intestinal NKp46+NK cells and CD14+LPMφs is an important participant in the pathogenesis of Crohn's disease. IL-23 and the TL1A were the key factor of their interaction. These findings suggest that IFN-γ-producing NKp46+mucosal NK cell subset is involved in the pathogenesis of Crohn's disease.