The role of Paraoxonase-1 in chronic kidney disease and renovascular injury

在大鼠5/6肾切除模型上进行PON1的免疫组织化学染色。提示PON1在血管内皮细胞中的表达与肾血管损伤有关。然后，我们研究了PON1基因(Rs662)与终末期肾病患者预后的关系。然而，PON1基因与存活率之间无显著差异，提示PON1基因与终末期肾病患者心血管疾病的风险及预后无关。

We performed immunohistochemistry for PON1 in rat 5/6 nephrectomy model. It showed that PON1 expression in vascular endothelium was associated with renovascular injury. Then we examined the association of PON1 genotype (rs662) and prognosis among patients with end-stage renal disease. However, there was no significant difference between survival rate and PON1 genotype, suggesting that PON1 gene was not associated with the risk of cardiovascular disease and prognosis in end-stage renal disease.