Fabrication of apatite bone substitutes designed on bone tissue compatibility

为了提高碳酸盐磷灰石骨替代物的骨替代能力，本研究对包括孔隙掺入以及化学成分和结晶度在内的整体设计进行了研究。将10wt%的球形PMMA颗粒引入石膏硬化体中烧坏，然后用碳酸盐溶液进行水热处理，得到方解石组成的前驱体多孔体。前驱体可转化为碳酸盐磷灰石，具有足够的处理性能。大鼠体内实验表明，新骨融入到获得的多孔体的孔隙结构中。结果表明，该方法可用于碳酸盐磷灰石骨替代物的多孔结构设计。

In order to increase an ability of bone replacement for carbonate apatite bone substitutes, an integrated design including pore incorporation as well as chemical composition and crystallinity was examined in this study. 10wt% spherical PMMA particles was introduced into gypsum hardening body and burned out then subsequently hydrothermally treated with carbonate solution to obtain the precursor porous body consisting of calcite. The precursor could transform to carbonate apatite with enough handling property. In vivo experiment using rats indicated the incorporation of new bone into the pore structure of the obtained porous body. It was concluded that the present method using spherical PMMA particles would be useful to make design of porous structure for carbonate apatite bone substitutes.