Sugar-alcohol for oral mucosal wetness and caries control strategy in compromised child patients

口腔黏膜炎是接受化疗和/或放疗的患者所经历的一种非常常见和潜在的严重并发症，它经常导致显著的发病率和死亡率，并降低生活质量，而且费用很高。口干的情况对龋齿、牙周病和真菌感染的发生也有影响。尽管其严重和流行，没有标准的管理，特别是在儿童。本研究评估木糖醇喷雾剂用于全身性疾病患儿的可行性。结果表明，木糖醇喷雾剂可有效降低唾液和牙菌斑中的MS水平，提高口腔水分，从而改善口腔状况。

Oral mucositis is a very frequent and potentially severe complication experienced by patients receiving chemotherapy and/or radiotherapy, which often leads to significant morbidity and mortality, and decreased quality oflife, and is very costly. The condition of dry mouth is also influential in occurrence of caries, periodontal disease and fungal infection. Despite its severity and prevalence, there has been no standard management especially in children. This study evaluated the feasibility of a xylitol spray for the child patients with systemic disease. The results suggest that a xylitol spray is effective on reduction of MS levels in saliva and plaque, and enhancing oral moisture, which leads to improvement of oral conditions.