Development of bioactive orthodontic mini-screw with nano-apatite layer

在这项研究中，我们对钛合金进行了两种表面修饰，以提高其生物功能活性。采用3%H_2O_2水热处理方法对Ti-6Al-4V盘片进行了表面处理。在处理后的表面观察到了纳米结构的多孔网状结构的二氧化钛。此外，将TiO2TiO2盘浸泡在过饱和的磷酸钙溶液中，形成纳米磷灰石层。我们对FGF2涂层的表面分析和生物活性进行了评价。结果表明，细胞增殖和细胞分化程度显著提高，生物功能活性增强。

In this study, we have developed two surface modifications of titanium alloy that improves its biofunctional activity. The surface of a Ti-6Al-4V disk was modified by applying 3% H2O2 hydrothermal treatment using an autoclave. A nanostructured porous network TiO2 was observed on the treated surface. Furthermore, the TiO2 titan disks were immersed in the supersaturated calcium phosphate solution to formed nano-apatite layer. We evaluated the surface analysis and bioactivities for FGF2 coated modified surfaces. As the results, significantly higher cell proliferation and celldifferentiation were exhibited, and enhanced biofunctional activity.