Are affective disorder for school-age children influenced by dietary habit and environmental chemical compounds ?

近年来，学习障碍和情感障碍儿童增多，我们曾报道环境污染化合物苯甲酸锌对A型单胺氧化酶(MAOA)有抑制作用。在本报告中，我们研究了锌和苯甲酸锌对MAOA活性的影响。对饲喂锌、苯甲酸锌或苯甲酸钠的小鼠脑组织的显微阵列分析表明，钙信号转导和神经活性配体-受体相互作用的基因调控发生了变化。

Recently, children with learning disabilities and affective disorder are increasing.We previously reportedthat zinc benzoate, a contaminating environmentalcompound, inhibited A-type monoamine oxidase (MAOA). In this report, we investigated how zinc and zinc benzoate influenced activity of MAOA. Microarrayanalysis of brain tissues isolated from mice fed zinc, zinc benzoate or sodium benzoate diets revealed that the regulation of genes involved calcium signal transduction and neuroactive ligand-receptor interactionwere changed.