Mechanisms of bone metastasis of tumor cells by endothelial-mesenchymal transition of vascular endothelial cells.

我们阐明了人类滑膜肉瘤和口腔癌细胞分别通过依赖于src的血管内皮生长因子的产生和口腔环境特异性的RANKL诱导血管内皮细胞进入肿瘤。此外，利用我们建立的体外3D培养系统，滑膜肉瘤细胞侵袭到人脐静脉内皮细胞形成的管内，导致内皮间质转化等形态改变，导致滑膜肉瘤细胞与滑膜肉瘤细胞合并形成异常的管状结构。

We clarified that human synovial sarcoma and oral cancer cells induced vascular endothelial cells into the tumors by Src-dependent VEGF production and oral environment specific induction of RANKL, respectively. In addition, using in vitro 3D culture system we have established, synovial sarcoma cells aggressively invaded into the tubes formed by HUVECs, leading to the morphological alterations like endothelialmesenchymal transition in HUVECs, resulted in the aberrant tube formation combined with synovial sarcoma cells.