Development of Au-Ag nanorods for application of hyperthermic treatment

纳米技术是许多领域的有用工具。特别是纳米材料在诊断、成像工具和治疗工具方面具有优势。金纳米材料，即金胶体和金纳米棒，目前已成为生物技术成像工具和癌症治疗的热点。我们研究了生物功能和化学功能材料的高分子合成，开发了稳定金纳米粒子的新型分散剂。该分散剂以吡啶与聚乙二醇（PEG）的接枝共聚物PEG-g- py为抗蛋白质吸附垂链，用于稳定金纳米棒。此外，金纳米棒具有光热转换性能的潜力。为了提高癌症光热治疗的光热转换效率，我们开发了银薄层包覆金纳米棒（PEG-g-Py包覆金纳米棒）。研究了PEG-g-Py包覆金-银纳米棒的新材料表征。我们证实了PEG-g-Py包覆的金-银纳米材料可以应用于癌症光热治疗。

Nanotechnology is useful tools for various fields. In particular, nanomaterials have advantage in application of diagnostic, imaging tools and therapeutic tools. Gold nanomaterials, gold colloid and gold nanorods, now were focused on imaging tool of biotechnology and cancer therapy. We have researched polymer synthesis of bio-and chemical-functional materials and developed new dispersing agent to stabilize gold nanoparticles. This dispersing agent which PEG-g-Py Graft copolymer made from pyridine and poly(ethylene glycol)(PEG) as protein adsorption-resistant pendant chains was used to stabilize gold nanorods. Moreover gold nanorods have potential of photothermal conversion property. We developed Silver thin layer coated gold nanorods(PEG-g-Py coated Gold-Silver nanorods) to increase the photothermal conversion efficiency for cancer photothermal therapy. We researched new materials characterization of PEG-g-Py coated Gold-Silver nanorods. We confirmed that PEG-g-Py coated Gold-Silver nanordos could apply cancer photothermal therapy.