Development of highly-selective antimicrobial agents based on the concept of polymer architecture

在这项研究中，我们开发了受天然宿主防御肽特征启发的新型抗菌聚合物。膜摄动是一种很有前途的方法，可以在最小化耐药细菌产生的情况下实现抗菌活性。结果表明，通过适当调整聚合物结构，可以控制聚合物与细胞膜的相互作用。因此，抗菌活性和对哺乳动物细胞的毒性可以通过改变聚合物结构来调节。

In this study, we developed novel antimicrobial polymers inspired by the features of natural host-defense peptides. Membrane perturbation, which is utilized in this study, is promising approach to achieve antimicrobial activity with minimized production of drug-resistant bacteria. It was clarified that we can control interaction of the polymers with cell membranes by proper tuning of polymer structure. As a result, antimicrobial activity and toxicity to mammalian cells can be tuned by changing polymer structure.