The factor of muscle strain recurrence

背景与目的：肌肉拉伤是最常见的软组织损伤之一，复发率高。我们假设损伤部位肌细胞基底层的损伤导致这些再损伤。本研究的目的是确定是否应变损伤的肌细胞的基底层或not.Methods和结果：18只成年Wistar雄性大鼠分为三组：应变损伤组，挫伤组，对照组。损伤后两天，腓肠肌肌肉被删除，这些肌肉细胞的基膜和质膜，通过免疫组化染色，使用laminine和dystrophin抗体进行鉴定。应变损伤肌细胞的基膜增厚、不规则。这些肌细胞的基膜比（基膜面积/横截面积）显着大于controls.Conclusion：本研究表明，肌细胞的基膜损伤的应变损伤，这些结果表明，基膜的损害可能涉及抑制卫星细胞的活动，延迟肌肉再生过程。这可能会增加再次受伤的几率。

Background and purpose : Muscle strain is one of the most common soft tissue injuries, and has a high recurrence rate. We hypothesized that damage of the basal lamina of the muscle cells at the injury site causes these re-injuries. The purpose of this study was to determine whether strain injury damages the basal lamina of muscle cells or not.Methods and results : Eighteen Wistar adult male rats were divided into three groups : strain injury group, contusion injury group, and control group. Two days after injury, the gastrocnemius muscles were removed and the basal lamina and plasma membrane of these muscle cells were identified by immunohistochemical staining using laminine and dystrophin antibodies. The basal lamina of strain injured muscle cells was thick and irregular. The basal lamina ratio(basal lamina area/cross-sectional area) of these muscle cells was significantly larger than those of controls.Conclusion : The present study indicated that the basal lamina of muscle cells was damaged by strain injury, and these results suggest that the damage of basal lamina may involve inhibition of satellite cell activities and delay the muscle regeneration processes. This may enhance the odds for re-injury.