The effect on vascular endothelial function by physical stimuli and the differences in the influence by lifestyle

本研究的目的是确定外周血管的热或冷刺激是否对内皮功能有影响。参与者为30名健康男性（20-21岁，吸烟者15名，非吸烟者15名）。比较吸烟组和不吸烟组，比较各组基线、热刺激后、冷刺激后的RHI值。吸烟组与非吸烟组RHI差异有统计学意义（p<0.01）。在基线、热刺激和冷刺激后的RHI比较无显著差异。这表明，即使吸烟年龄小、吸烟时间短，吸烟的化学损伤也会对血管内皮的血管扩张功能产生影响。

The purpose of this study was to determine whether thermal or cold stimuli for peripheral vessel have an influence on endothelium function. The participants were 30 healthy men(20-21 years old, smoker 15 men and non-smoker 15 men). The smoking group and non-smoking group were compared, and RHI values of baseline, after thermal stimulus, and after cold stimulus in each group were compared. Significant difference was observed between smoking and non-smoking group with RHI(p<0.01). There was no significant difference in the comparison of RHI between baseline, after thermal stimulus, and after cold stimulus. This suggests that even if younger and short smoking duration, the chemical damage by smoking exert influence on vascular dilatation function derived from vascular endothelium.