The effect of Notch signaling on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma

在体外，Delta样4-选择性中和抗体治疗显着损害恶性间皮瘤（MM）细胞系的细胞增殖率，这是伴随着磷酸化p53水平的增加。这些作用部分涉及对MM细胞的生长停滞的诱导。在体内，用Delta样4-选择性中和抗体和γ-分泌酶抑制剂（Notch信号传导的抑制剂）处理没有显著降低MM的生长速率。最后，Delta样4-选择性中和抗体处理也没有显著延长MM的植入动物模型中的存活间隔。

In vitro, Delta-like 4-selective neutralizing antibody treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines, which was accompanied by an increase in phosphor-p53 levels. These effects partly involved induction of growth arrest to MM cells. In vivo, treatments with Delta-like 4-selective neutralizing antibody andγ-secretase inhibitor (an inhibition of Notch signaling)not significantly decreased the growth rate of MM. Finally, Delta-like 4-selective neutralizing antibody treatment also not significantly extended survival interval in an implant animal model of MM.