Analysis of genome-wide DNA methylation profiles of the brain in mice exposed to diesel exhaust during fetal period.

将柴油机尾气(DE)暴露于妊娠小鼠，并从其后代中提取基因组DNA。随后，进行全基因组DNA甲基化分析。结果表明，孕期DE暴露破坏了子代大脑DNA甲基化模式的构建。这也表明，DNA甲基化模式的破坏在生长过程中持续存在。我们的研究结果为阐明孕期DE暴露所致脑功能损害的效应和机制提供了重要信息。

Diesel exhaust(DE) was exposed to pregnant mice and genomic DNA was obtained from offspring. Subsequently, genome-wide DNA methylation analysis was performed. The results indicated that prenatal DE exposure disrupts the construction of DNA methylation pattern in the brain of offspring. It is also suggested that disrupted DNA methylation pattern is sustained during growth. Our findings provide the important information to clarify the effects and mechanisms of functional impairment of the brain induced by prenatal DE exposure.